The ongoing Bone on ISS experiment studies the effects of microgravity on bone health, focusing on bone loss and recovery post-spaceflight. By examining bone markers, inflammation, and growth factors, the study aims to develop a digital twin model to predict bone behavior during recovery. This research is crucial for space missions, as it helps predict individual skeletal risks and enables better astronaut screening. The findings will benefit Earth by advancing the understanding of bone disorders and improving treatments for conditions like osteoporosis, helping populations prone to bone fragility and immobility.