The Italian company GVM is creating a telemedicine platform that could be used in the future to monitor and manage the health of astronauts before, during, and after human spaceflight missions. This ground-based study will investigate the cardiovascular physiology and health of the crew before and after the Ax3 mission and will simulate on-orbit video consultations. The team will collect and monitor data from wearable devices and a health app before and after flight. The platform is being developed to gain a thorough understanding of astronaut health and enable medical advice and treatment discussions with the crew.