MemoBC
Direct and Delayed Effects of Microgravity on "Space Memory" of Neural Crest Stem Cells
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MISSIONS
PUBLICATIONS
MEDIA
Life Science
The experiment aims to determine the direct and delayed post-flight effects on neural stem cells after long-term microgravity exposure and investigate if the delayed effects are the result of genetic changes emerging during microgravity or to secreted components in the medium during the flight. Elucidating delayed effects of microgravity may contribute to the development of new protocols for microgravity exploitation in biomedicine.
PUBLICATION
Boundary cap neural crest stem cells exhibit remarkable resilience to environmental stressors associated with International Space Station mission
- Survival of stem cells was uneven and unexpectedly linked to prior spaceflight history on sounding rockets
- Surviving cells retained full differentiation and normal electrical function despite the ordeal
- Proliferation patterns flipped compared to earlier short-duration missions on sounding rockets
- 3D-printed scaffolds dramatically improved survival and proliferation
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