Spaceflight can be a stressful experience for the human body to adapt to changes in microgravity, such as physical demands, nutritional changes, and lack of sleep. The physiological changes can be monitored by profiling the "'omics" of the body — the changes in gene expression (genomics), protein expression (proteomics) or metabolites (metabolomics). A better understanding of these changes in an individual's response to spaceflight can help to develop personalized countermeasure procedures that can optimize the safety and performance of each astronaut. This project aims to gather data to better understand omics changes seen after spaceflight and inform Turkish researchers working on gravitational physiology, aviation, and space medicine on best practices for astronaut care, as part of Türkiye’s rapidly developing national space program.