This project aims to identify the pathways responsible for skeletal muscle dysfunction in microgravity and explore therapeutic targeting strategies. By studying how muscle loss occurs in space, the project seeks to pinpoint specific molecular mechanisms and potential interventions. Understanding these pathways is crucial for developing treatments to prevent muscle atrophy in astronauts during long space missions. On Earth, the findings could also impact the understanding of and treatments for muscle-related diseases and conditions related to aging or prolonged immobility.