Architecture is known to play a crucial role in shaping physical and social environments and have a direct impact on human physical and psychological well-being. This study aims to investigate the effects of architectural settings, as well as its properties on an astronaut’s cognitive performance, stress levels, and stress recovery rate. This activity looks to study the effects between the above-mentioned factors in isolated and confined environments on Earth and in space analog missions, which are similarly observed in the environment of a space station.